trans-Cyclooctene—a stable, voracious dienophile for bioorthogonal labeling
نویسندگان
چکیده
منابع مشابه
Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7ob01707c
The use of organic chemistry principles and prediction techniques has enabled the development of new bioorthogonal reactions. As this "toolbox" expands to include new reaction manifolds and orthogonal reaction pairings, the continued development of existing reactions remains an important objective. This is particularly important in cellular imaging, where non-specific background fluorescence ha...
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ژورنال
عنوان ژورنال: Current Opinion in Chemical Biology
سال: 2013
ISSN: 1367-5931
DOI: 10.1016/j.cbpa.2013.07.031